Background：Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.JNK2 isoforms display different binding patterns： alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
仕様
Synonyms：c Jun kinase 2,C Jun N terminal kinase 2,c-Jun N-terminal kinase 2,JNK 55,JNK-55,JNK2 alpha,JNK2,JNK2 beta,JNK2A,JNK2alpha,JNK2B,JNK2BETA,Jun kinase,MAP kinase 9,MAPK 9,Mapk9,Mitogen activated protein kinase 9,Mitogen-activated protein kinase 9,MK09,P54a,p54aSAPK,PRKM9,Protein kinase,mitogen-activated,9,SAPK alpha,SAPK,SAPK1a,Stress activated protein kinase 1a,Stress-activated protein kinase JNK2
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Synthetic peptide of human MAPK9
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000, IHC 1：25-1：100
Swissprot：P45984
Isotype：IgG
Research Areas：Cancer, Cell Biology, Metabolism, Immunology, Signal transduction
