Background：This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc（-）, the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas （compared to normal brain tissue） was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
仕様
Synonyms：Amino acid transport system xc xCT,Amino acid transport system xc-,Calcium channel blocker resistance protein CCBR1,Calcium channel blocker resistance protein CCBR1,CCBR1,Cysteine/glutamate transporter,Cystine/glutamate transporter,OTTHUMP00000164578,SLC7A11,Solute carrier family 7 （anionic amino acid transporter light chain,xc- system）,member 11,solute carrier family 7,Solute carrier family 7 member 11,Solute carrier family 7,（cationic amino acid transporter,y+ system） member 11,SYSTEM Xc（-） TRANSPORTER-RELATED PROTEIN,xCT,XCT
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Synthetic peptide of human SLC7A11
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：20-100, ELISA 1：2000-5000
Swissprot：Q9UPY5
Isotype：IgG
Research Areas：Cancer, Cell Biology, Metabolism, Signal transduction
