Background：The protein encoded by this gene is a cytokine structurally related to interleukin 10 （IL10）. This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 （STAT3） in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.
