Background：Regulator of the DNA damage response （DDR）. Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase （PIKK） family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation （IR）, ultraviolet （UV） and mitomycin C （MMC）. Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
仕様
Synonyms：smg-10,KIAA0406
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.7mg/mL
Immunogen：Synthetic peptide of human TTI1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-100, ELISA 1：2000-5000
Swissprot：O43156
Isotype：IgG
Research Areas：Cell Biology, Epigenetics and Nuclear Signaling
