Background：The protein encoded by this gene is a member of the superfamily of ATP-binding cassette （ABC） transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies （ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White）. This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular （apical） part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome （DJS）, an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
仕様
Synonyms：ABC30,abcC2,ATP binding cassette sub family C （CFTR/MRP） member 2,ATP binding cassette subfamily C member 2,ATP-binding cassette sub-family C member 2,Canalicular multidrug resistance protein,Canalicular multispecific organic anion transporter 1,CMOAT,CMOAT1,cMRP,DJS,KIAA1010,MRP 2,MRP2,Multidrug resistance associated protein 2,Multidrug resistance-associated protein 2
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.6mg/mL
Immunogen：Synthetic peptide of human ABCC2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：30-150, ELISA 1：2000-10000
Swissprot：Q92887
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction
