Background：After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides： the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor （INSR） stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
仕様
Synonyms：IDDM,IDDM1,IDDM2,ILPR,ins,INS,Insulin A chain,Insulin B chain,IRDN,MODY10,Preproinsulin,Proinsulin,Proinsulin precursor
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Synthetic peptide of human Insulin
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-100, ELISA 1：2000-5000
Swissprot：P01308
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Neuroscience, Signal transduction
