Background：The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein （MAP） kinase superfamily （MAPK/ERK, SAPK/JNK, p38）, which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism.
仕様
Synonyms：Dual specificity phosphatase 11,Dual specificity protein phosphatase 11,DUS11,DUSP11,Phosphatase that interacts with RNA/RNP complex 1,PIR1,RNA/RNP complex 1 interacting,RNA/RNP complex interacting phosphatase,RNA/RNP complex-1-interacting phosphatase,RNA/RNP complex1 intereracting phosphatase,Serine/threonine specific protein phosphatase
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：1.5mg/mL
Immunogen：Full length fusion protein
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：30-150, ELISA 1：2000-10000
Swissprot：O75319
Isotype：IgG
Research Areas：Epigenetics and Nuclear Signaling, Signal transduction
