Background：This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid （THP-1） cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha （CCAAT/enhancer-binding protein alpha） and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
仕様
Synonyms：C5FW,FLJ57420,GS3955,Hypothetical protein TRB2,TRB-2,TRB2,TRIB 2,TRIB2,TRIB2,Tribbles homolog 2
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Full length fusion protein
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：30-150, ELISA 1：2000-10000
Swissprot：Q92519
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Signal transduction, Stem cells
