Background：The innate immune system recognizes microbial pathogens through Toll-like receptors （TLRs）, which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor （TIR） domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
仕様
Synonyms：Adapter protein wyatt,FLJ42305,MAL,MyD88 adapter like protein,TIR domain containing adapter protein,Toll interleukin 1 receptor （TIR） domain containing adaptor protein,Toll interleukin 1 receptor domain containing adapter protein,Toll like receptor adaptor protein,Wyatt
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Full length fusion protein
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-100, ELISA 1：2000-5000
Swissprot：P58753
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Immunology, Signal transduction
