Background：This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signaling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
仕様
Synonyms：dJ537F10.1,Inactive tyrosine protein kinase transmembrane receptor ROR1,MGC99659,Neurotrophic tyrosine kinase,Neurotrophic tyrosine kinase receptor related 1,Neurotrophic tyrosine kinase,receptor related 1,NTRKR1,OTTHUMP00000010573,OTTHUMP00000010574,OTTMUSP00000008344,Receptor tyrosine kinase like orphan receptor 1,receptor-related 1,RGD1559469,ROR 1,ROR1,ROR1,RP11 24J23.1,Tyrosine kinase like orphan receptor 1,Tyrosine protein kinase transmembrane receptor ROR1,Tyrosine-protein kinase transmembrane receptor ROR1
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Synthetic peptide of human ROR1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：Q01973
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction
