Background：This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation.
仕様
Synonyms：1110002G11Rik,AU044290,MGC118148,MGC138241,MGC142129,OTTMUSP00000022799,p53 activated gene 26,p53 regulated PA26 nuclear protein,p53 regulated protein PA26,p53-regulated protein PA26,PA26,RP11-787I22.1,sesn1,SESN1,SEST1,sestrin 1,Sestrin-1
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,ELISA
Concentration：0.4mg/mL
Immunogen：Synthetic peptide of human SESN1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
