Background：This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t（8;21）（q22;q22） translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.
仕様
Synonyms：Acute myelogenous leukemia 1 translocation 1 cyclin D related,Acute myelogenous leukemia 1 translocation 1 protein,AML1 MTG8,AML1T1,CBFA2T1,CDR,Core binding factor runt domain alpha subunit 2 translocated to 1,Core binding factor runt domain alpha subunit 2 translocated to 1 cyclin D related,Cyclin D related,Cyclin D related protein,Cyclin-D-related protein,Eight twenty one protein,ETO,ETO protein,MGC2796,MTG 8,MTG 8b,MTG8,MTG8 protein,MTG8,MTG8b,Myeloid translocation gene on 8q22,Protein CBFA2T1,Protein ETO,Protein MTG 8,Protein MTG8,Runt related transcription factor 1 translocated to 1 （cyclin D related）,Runt related transcription factor 1 translocated to 1,Runt related transcription factor 1 translocated to 1 cyclin D related,RUNX1 translocation partner 1,RUNX1T1,Zinc finger MYND domain containing protein 2,Zinc finger MYND domain-containing protein 2,ZMYND 2,ZMYND2
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.3mg/mL
Immunogen：Synthetic peptide of human RUNX1T1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：Q06455
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
