Background：This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic Nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.
仕様
Synonyms：Circadian clock protein PERIOD 2,FASPS,FASPS1,hPER 2,hPER2,KIAA0347,OTTHUMP00000164476,PER 2,PER2,PER2,Period 2,Period 2 isoform 1,Period circadian clock 2,Period circadian protein 2,Period circadian protein homolog 2,Period homolog 2 （Drosophila）,Period homolog 2,Period,Drosophila,homolog of,2,Period2
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.6mg/mL
Immunogen：Synthetic peptide of human PER2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：100-1：300
Swissprot：O15055
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Neuroscience, Signal transduction
