Background：This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol.
仕様
Synonyms：Niemann Pick C1 protein precursor,Niemann Pick disease,type C1,Niemann-Pick C1 protein,NPC,NPC1,NPC1
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.9mg/mL
Immunogen：Synthetic peptide of human NPC1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：O15118
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Neuroscience, Signal transduction
