Background：NAP125, also known as NCKAP1 （NCK-associated protein 1）, p125Nap1 or membrane-associated protein HEM-2, is a 1,128 amino acid single pass membrane protein that exists as two alternatively spliced isoforms and belongs to the HEM-1/HEM-2 family. While widely expressed, NAP125 is found at highest levels in heart, brain and skeletal muscle where it regulates Rac-dependent actin remodeling as part of a lamellipodial complex with WAVE2, Abi-1 and CYFIP1. NAP125 localizes to the cytoplasmic side of lamellipodium membrane and is encoded by a gene that maps to human chromosome 2q32.1 and mouse chromosome 2 C3. NAP125 expression is markedly reduced in Alzheimer disease （AD）-affected brains, suggesting a possible role in the disease.
仕様
Synonyms：FLJ11291,KIAA0587,Membrane associated protein HEM2,Membrane-associated protein HEM-2,MGC8981,NAP 1,NAP1,NAP125,NCK associated protein 1,NCK associated protein,Nck-associated protein 1,Nckap1,NCKP1,OTTHUMP00000163460,OTTHUMP00000163461,p125Nap1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.6mg/mL
Immunogen：Synthetic peptide of human NCKAP1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：Q9Y2A7
Isotype：IgG
Research Areas：Cancer, Cell Biology, Neuroscience, Signal transduction
