Background：This gene encodes one of the SERCA Ca（2+）-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms.
仕様
Synonyms： fast twitch skeletal muscle isoform,AT2A1,ATP2A,ATP2A1,ATPase Ca++ transporting cardiac muscle fast twitch 1,ATPase Ca++ transporting fast twitch 1,ATPase,Ca（2+）-transporting fast twitch 1,Calcium pump 1,Calcium transporting ATPase sarcoplasmic reticulum type fast twitch skeletal muscle isoform,Calcium-transporting ATPase sarcoplasmic reticulum type,EC 3.6.3.8,Endoplasmic reticulum class 1/2 Ca（2+） ATPase,Fast skeletal muscle SR calcium ATPase,OTTHUMP00000162561,OTTHUMP00000162562,Sarcoendoplasmic reticulum calcium ATPase,Sarcoplasmic reticulum Ca（2+）-ATPase 1,Sarcoplasmic/endoplasmic reticulum calcium ATPase 1,SERCA 1,SERCA1,SERCA1 truncated isoform,included,SR Ca（2+） ATPase 1,SR Ca（2+）-ATPase 1
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.7mg/mL
Immunogen：Synthetic peptide of human ATP2A1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：O14983
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Signal transduction, Tags ＆ Cell Markers
