Background：EMP-2 （epithelial membrane protein 2）, also known as XMP, is a 167 amino acid multi-pass membrane protein that contains four-transmembrane domains and belongs to the GAS3/PMP22 （growth arrest-specific-3/peripheral myelin protein-22） family. Localized to lipid raft domains in the plasma membrane, EMP-2 regulates the expression of several target proteins and is necessary for blastocyst implantation in the uterine endometrium. Specifically, EMP-2 mediates blastocyst implantation by controlling the cell membrane expression of MHC and glycosylphosphatidylinositol-anchored proteins, as well as Integrins and caveolin-1. In adult tissues, EMP-2 is expressed in heart, lung, ovary and intestine, while fetal expression is highest in kidney, brain and liver. Overexpression of EMP-2 is associated with endometrial adenocarcinoma, suggesting a possible role for EMP-2 in tumorigenesis.
仕様
Synonyms：EMP 2,EMP-2,EMP2,EMP2,Epithelial membrane protein 2,Protein XMP
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.8mg/mL
Immunogen：Synthetic peptide of human EMP2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：P54851
Isotype：IgG
Research Areas：Cancer, Developmental biology, Signal transduction
