Background：The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein （MAP） kinase superfamily （MAPK/ERK, SAPK/JNK, p38）, which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.
仕様
Synonyms：Dual specificity phosphatase 2,Dual specificity protein phosphatase 2,Dual specificity protein phosphatase PAC 1,Dual specificity protein phosphatase PAC-1,DUS2,DUSP 2,DUSP2,PAC 1,PAC1,Serine/threonine specific protein phosphatase
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC,ELISA
Concentration：0.3mg/mL
Immunogen：Synthetic peptide of human DUSP2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：200-1：1000, IHC 1：25-1：100
Swissprot：Q05923
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
