Background：The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon （IFN）, this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 （ISGF3G）, in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP （EP300/CREBBP） has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.
仕様
Synonyms：Homo sapiens interferon alpha induced transcriptional activator,interferon alpha induced transcriptional activator,ISGF 3,ISGF3,MGC59816,P113,signal transducer and activator of transcription 2 113kD,Signal transducer and activator of transcription 2,STAT113,Stat2,STAT2
Host：Rabbit
Reactivity：Human
Applications：WB,IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Synthetic peptide of human STAT2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000, IHC 1：50-1：200
Swissprot：P52630
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Signal transduction
