Background：The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats （type III）, is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH （corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus）. Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.
仕様
Synonyms：Antigen identified by monoclonal R1,CAML1,CD171,CD171 antigen,HSAS,HSAS1,Hyd,L1,L1 cell adhesion molecule,L1-NCAM,L1cam,L1CAM,MASA,MIC5,N CAML1,N-CAM-L1,NCAM-L1,NCAML1,Nerve-growth factor-inducible large external glycoprotein,Neural cell adhesion molecule L1,NILE,OTTHUMP00000025992,S10,SPG1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.3mg/mL
Immunogen：Synthetic peptide of human L1CAM
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：P32004
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction
