Background：Phosphoinositide 3-kinase regulatory subunit 4, also known asPI3-kinase regulatory subunit 4orPI3-kinase p150 subunitorphosphoinositide 3-kinase adaptor protein, orVPS15is an enzyme that in humans is encoded by thePIK3R4gene. The PI3-kinases regulate cellular signaling networks that are involved in processes linked to the survival, growth, proliferation, metabolism and specialized differentiated functions of cells. The subversion of this network is common in cancer and has also been linked to disorders of inflammation.
