Background：Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor （AR）-induced gene activation.
仕様
Synonyms：2A-DUB,2ADUB,Histone H2A deubiquitinase,Histone H2A deubiquitinase MYSM1,KIAA1915,Myb like SWIRM and MPN domains 1,Myb like,SWIRM and MPN domain containing protein,Myb like,SWIRM and MPN domains 1,Myb-like,Myb-like,SWIRM and MPN domains 1,MYSM 1,mysm1,MYSM1 Myb-like,SWIRM and MPN domains 1,MYSM1,RP4-592A1.1,SWIRM and MPN domain-containing protein 1
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC,ELISA
Concentration：0.7mg/mL
Immunogen：Synthetic peptide of human MYSM1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000, IHC 1：50-1：200
Swissprot：Q5VVJ2
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
