Background：TMEM16A, also known as DOG1, ORAOV2, TAOS2 or ANO1 （anoctamin 1）, is a 986 amino acid multi-pass membrane protein that localizes to both the cell membrane and the cytoplasm and belongs to the anoctamin family. Expressed in a variety of tissues with highest expression in skeletal muscle and liver, TMEM16A functions as a calcium-activated chloride channel that is required for normal tracheal development. Human TMEM16A shares 90％ sequence identity with its mouse counterpart, suggesting a conserved role between species. TMEM16A is present in breast, pancreatic, gastric, and uterine cancers, as well as in neck, ovarian and parathyroid tumors, suggesting a role for TMEM16A in carcinogenesis. Three isoforms of TMEM16A exist due to alternative splicing events.
仕様
Synonyms：ANO 1,ANO1,ANO1,Anoctamin 1,Anoctamin 1 calcium activated chloride channel,Anoctamin-1,Anoctamin1,Ca2+ activated Cl- channel,Calcium Activated Chloride Channel,Discovered on gastrointestinal stromal tumors protein 1,DOG 1,DOG1,FLJ10261,Membrane protein,Oral cancer overexpressed 2,Oral cancer overexpressed protein 2,ORAOV 2,ORAOV2,TAOS 2,TAOS2,TMEM 16A,TMEM16A,Transmembrane protein 16A （eight membrane spanning domains）,Transmembrane protein 16A,Tumor amplified and overexpressed sequence 2,Tumor-amplified and overexpressed sequence 2
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Synthetic peptide of human ANO1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
