Background：This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
仕様
Synonyms：FLJ13161,Kinase phosphorylated during mitosis protein,KPM,Large tumor suppressor homolog 2,Large tumor suppressor homolog 2 Drosophila,Large tumor suppressor kinase 2,LATS large tumor suppressor Drosophila homolog 2,LATS large tumor suppressor homolog 2,Lats2,LATS2,Serine/threonine kinase kpm,Serine/threonine protein kinase kpm,Serine/threonine-protein kinase kpm,Serine/threonine-protein kinase LATS2,Warts like kinase,Warts-like kinase
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Synthetic peptide of human LATS2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：Q9NRM7
Isotype：IgG
Research Areas：Epigenetics and Nuclear Signaling, Signal transduction
