Background：The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 （TGFBR1）, leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 （CRCS3）. Several transcript variants encoding different isoforms have been found for this gene.
仕様
Synonyms：CRCS3,FLJ16482,hSMAD 7,hSMAD7,MAD （mothers against decapentaplegic Drosophila） homolog 7,MAD,Mad homolog 7,MAD homolog 8,MAD mothers against decapentaplegic homolog 7,MADH 7,MADH 8,MADH6,MADH8,Mothers Against Decapentaplegic Drosophila Homolog of 6,Mothers Against Decapentaplegic Drosophila Homolog of 7,Mothers against decapentaplegic homolog 7,Mothers against decapentaplegic homolog 8,Mothers against DPP homolog 7,Mothers against DPP homolog 8,SMA- AND MAD-RELATED PROTEIN 7,SMAD 7,SMAD,SMAD family member 7,SMAD,mothers against DPP homolog 7 （Drosophila）,SMAD,mothers against DPP homolog 7,SMAD6,Smad7,SMAD7
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Synthetic peptide of human SMAD7
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：O15105
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Signal transduction
