Background：N-methyl-D-aspartate （NMDA） receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 （GRIN1） and 1 or more of the 4 NMDAR2 subunits： NMDAR2A （GRIN2A）, NMDAR2B （GRIN2B）, NMDAR2C （GRIN2C）, and NMDAR2D （GRIN2D）.
