Background：Laminin subunit alpha-1is aproteinthat in humans is encoded by theLAMA1gene. Laminin is a complex glycoprotein, consisting of three different polypeptide chains （alpha, beta, gamma）, which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 （laminin-111 or EHS laminin） and laminin-3 （laminin-121 or S-laminin）. Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
