Background：Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
仕様
Synonyms：Claudin-1,Claudin1,CLD 1,CLD1,CLD1,CLDN 1,Cldn1,ILVASC,SEMP 1,SEMP1,Senescence associated epithelial membrane protein 1,Senescence associated epithelial membrane protein,Senescence-associated epithelial membrane protein
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,ELISA
Concentration：1mg/mL
Immunogen：Synthetic peptide of human CLDN1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
