Background：This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
仕様
Synonyms：Blepharophimosis,Blepharophimosis epicanthus inversus and ptosis 1,Blepharophimosis epicanthus inversus and ptosis,BPES 1,BPES,BPES1,Epicanthus inversus and ptosis 1,Forkhead box L2,Forkhead box protein L2,Forkhead transcription factor FOXL2,FOX L2,FOXL 2,FOXL2,FOXL2,PFRK,PINTO,PITUITARY FORKHEAD FACTOR,POF 3,POF3
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,ELISA
Concentration：0.5mg/mL
Immunogen：Synthetic peptide of human FOXL2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000
Swissprot：P58012
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
