Background：This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif （ITAM） in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor （KIR） family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain （TCR） associated protein kinase 70kDa （ZAP-70） and spleen tyrosine kinase （SYK） and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy （PLOSL）, also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 （TREM2）, also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.
仕様
Synonyms：DAP 12,DAP12,DNAX activation protein 12,DNAX-activation protein 12,KAR-associated protein,KARAP,Killer activating receptor associated protein,Killer-activating receptor-associated protein,PLOSL,TYOBP,TYRO protein tyrosine kinase binding protein,TYRO protein tyrosine kinase-binding protein,TYROBP
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Synthetic peptide of human TYROBP
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
