Background：The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin （CCL11）, eotaxin-3 （CCL26）, MCP-3 （CCL7）, MCP-4 （CCL13）, and RANTES （CCL5）. It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described.
仕様
Synonyms：B chemokine receptor,b-chemokine receptor,C C chemokine receptor type 3,C C CKR 3,C-C chemokine receptor type 3,C-C CKR-3,CC chemokine receptor 3,CC chemokine receptor type 3,CC CKR 3,CC R3,CC-CKR-3,CCCKR3,CCR 3,CCR-3,CCR3,CCR3,CD 193,CD193,CD193 antigen,Chemokine （C C motif） receptor 3,chemokine （C-C motif） receptor 3,Chemokine （CC） receptor 1 like 2,Chemokine CC motif receptor 3,Chemokine receptor 3,CK R3,CKR 3,CKR3,CMKB R3,CMKBR 3,CMKBR1L2,CMKBR3,Eosinophil CC chemokine receptor 3,Eosinophil eotaxin receptor,Eotaxin receptor,Macrophage inflammatory protein 1 alpha receptor like 2,MGC102841,MIP1 Alpha RL2
Host：Rabbit
Reactivity：Human
Applications：WB,IHC,ELISA
Concentration：0.3mg/mL
Immunogen：Synthetic peptide of human CCR3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：200-1：1000, IHC 1：50-1：200
Swissprot：P51677
Isotype：IgG
Research Areas：Cancer, Immunology, Signal transduction
