Background：This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta （TGF-beta） superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I （I and IB） and two type II （II and IIB） receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
仕様
Synonyms：Activin A receptor type IIA,Activin receptor type 2A,Activin receptor type IIA,Activin receptor type-2A,ACTR 2,ACTR IIA,ACTR-IIA,ACTR2,ACTRII,ACTRIIA,Acvr 2,Acvr 2A,Acvr2,ACVR2A,AVR2A,OTTHUMP00000197918
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,ELISA
Concentration：1.2mg/mL
Immunogen：Synthetic peptide of human ACVR2A
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000
Swissprot：P27037
Isotype：IgG
Research Areas：Cancer, Metabolism, Signal transduction, Stem cells
