Background：Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms . The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure： an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A （NPR1） and type B （NPR2; MIM 108961）. Also see NPR3 （MIM 108962）, which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides （ANP （MIM 108780） and BNP （MIM 600295）, respectively）.
仕様
Synonyms：ANP-A,ANPa,ANPR-A,ANPRA,ANPRA,Atrial natriuretic peptide A type receptor,Atrial natriuretic peptide receptor 1,Atrial natriuretic peptide receptor A,Atrial natriuretic peptide receptor type A,Atrionatriuretic peptide receptor A,GC A,GC-A,Guanylate cyclase A,Guanylate cyclase,GUC2A,GUCY2A,Natriuretic peptide A type receptor,Natriuretic peptide receptor A/guanylate cyclase A,NPR-A,NPR1,NPRA
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Synthetic peptide of human NPR1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：P16066
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Signal transduction
