Background：The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase （AMPK）. AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase （ACC） and beta-hydroxy beta-methylglutaryl-CoA reductase （HMGCR）, key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
仕様
Synonyms：5' AMP activated protein kinase gamma 1 subunit,5' AMP activated protein kinase subunit gamma 1,5''-AMP-activated protein kinase subunit gamma-1,AAKG1,AMP activated protein kinase noncatalytic gamma 1 subunit,AMPK gamma 1 chain,AMPK gamma1,AMPK subunit gamma-1,AMPKg,MGC8666,PRKAG 1,PRKAG1,Protein kinase AMP activated gamma 1 non catalytic subunit,protein kinase,AMP-activated,noncatalytic gamma-1
Host：Rabbit
Reactivity：Human
Applications：WB,ELISA
Concentration：0.5mg/mL
Immunogen：Synthetic peptide of human PRKAG1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000
Swissprot：P54619
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Metabolism, Signal transduction
