Background：Placental ribonuclease inhibitor （PRI） is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases （summarized by Lee et al., 1988 [PubMed 3219362]）. In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin （MIM 105850）. Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form.
