Background：This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension.
仕様
Synonyms：E3 ubiquitin protein ligase NEDD4 like protein,E3 ubiquitin-protein ligase NEDD4-like,KIAA0439,NED4L,NEDD4 2,NEDD4 2c,Nedd4-2,NEDD4-2a,NEDD4.2,NEDD4b,NEDD4L,NEDD4La,NEDD4Lb,NEDD4Lc,NEDD4Ld,NEDD4Le,NEDD4Lf,NEDD4Lg,NEDD4Lh,NEDL3,Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase,Neural precursor cell expressed,developmentally down regulated 4 like,RSP5,Ubiquitin protein ligase Rsp5
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：1mg/mL
Immunogen：Recombinant protein of human NEDD4L
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：Q96PU5
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling
