Background：PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
仕様
Synonyms：FLJ10665,MGC126315,MGC126353,MGC126354,Myosin interacting guanine nucleotide exchange factor,PH domain containing family G member 6,Pleckstrin homology domain containing family G （with RhoGef domain） member 6,Pleckstrin homology domain-containing family G member 6,PLEKHG6
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,ELISA
Concentration：0.1mg/mL
Immunogen：Recombinant protein of human PLEKHG6
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000
Swissprot：Q3KR16
Isotype：IgG
Research Areas：Cancer, Cell Biology, Signal transduction
