Background：The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene.
仕様
Synonyms：MAP3K7IP 3,Mitogen-activated protein kinase kinase kinase 7-interacting protein 3,NAP1,NF-kappa-B-activating protein 1,NFkB activating protein 1,TAB-3,Tab3,TAB3,TAK1 binding protein 3,TAK1-binding protein 3,TGF-beta-activated kinase 1 and MAP3K7-binding protein 3,TGF-beta-activated kinase 1-binding protein 3
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,IHC,ELISA
Concentration：0.2mg/mL
Immunogen：Recombinant protein of human TAB3
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：200-1：1000, IHC 1：50-1：200
Swissprot：Q8N5C8
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling, Immunology, Signal transduction
