Background：The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1.
仕様
Synonyms：2310012M03Rik,3'-Tab1,MAP3K7IP 1,MAP3K7IP1,MGC57664,Mitogen activated protein kinase kinase kinase 7 interacting protein 1,Mitogen-activated protein kinase kinase kinase 7-interacting protein 1,TAB 1,TAB1,TAB1,TAK1 binding protein 1,TAK1-binding protein 1,TGF beta activated kinase 1 binding protein 1,TGF-beta activated kinase 1/MAP3K7 binding protein 1,TGF-beta-activated kinase 1 and MAP3K7-binding protein 1,TGF-beta-activated kinase 1-binding protein 1,Transforming growth factor beta activated kinase binding protein 1
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.2mg/mL
Immunogen：Recombinant protein of human TAB1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：Q15750
Isotype：IgG
Research Areas：Cancer, Cardiovascular, Immunology, Signal transduction
