Background：This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
仕様
Synonyms：DDIT 1,DDIT-1,DDIT1,DNA damage inducible transcript 1,DNA damage-inducible transcript 1 protein,GA45A,GADD45,GADD45A,Growth arrest and DNA damage inducible 45 alpha ,Growth arrest and DNA damage inducible alpha,Growth arrest and DNA damage-inducible protein GADD45 alpha
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Recombinant protein of human GADD45A
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：P24522
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
