Background：This gene is a member of the GRB2-associated binding protein （GAB） gene family. These proteins contain pleckstrin homology （PH） domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
仕様
Synonyms：GAB 2,Gab2,GAB2,Grb 2 associated binder 2,GRB 2 associated binding protein 2,Grb2 associated binder 2,GRB2 associated binder 2 pp100,GRB2 associated binding protein 2,GRB2-associated binder 2,GRB2-associated-binding protein 2,Growth factor receptor bound protein 2 associated protein 2,Growth factor receptor bound protein 2-associated protein 2,KIAA0571,p97,PH domain containing adaptor molecule p97,pp100
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：WB,IHC,ELISA
Concentration：0.2mg/mL
Immunogen：Recombinant protein of human GAB2
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：500-1：2000, IHC 1：50-1：200
Swissprot：Q9UQC2
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction
