Background：E1A-like inhibitor of differentiation-1 （EID-1）, an acetyltransferase enzyme, binds both the retinoblastoma protein （Rb）, a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.
仕様
Synonyms：21 kDa pRb associated protein,21 kDa pRb-associated protein,C15orf3,CBP,Chromosome 15 open reading frame 3,CREBBP/EP300 inhibitor 1,CREBBP/EP300 inhibitory protein 1,CRI 1,CRI1,E1A like inhibitor of differentiation,E1A-like inhibitor of differentiation 1,EID 1,EID-1,EID1,EID1,EP300 interacting inhibitor of differentiation 1,EP300-interacting inhibitor of differentiation 1,IRO45620,MGC138883,MGC138884,NB4 apoptosis related protein,PNAS 22,PNAS22,PTD014,Rb and p300 binding protein EID 1,Rb and p300 binding protein EID1,RBP21,Retinoblastoma protein associated protein
Host：Rabbit
Reactivity：Human
Applications：IHC,ELISA
Concentration：0.6mg/mL
Immunogen：Recombinant protein of human EID1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：Q9Y6B2
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal transduction
