Background：The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne （DMD） and Becker （BMD） Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination （nonsense or frame shift mutations）, while in BMD patients dystrophin is reduced either in molecular weight （derived from in-frame deletions） or in expression level.
仕様
Synonyms：BMD,CMD3B,DMD,DMD,Duchenne muscular dystrophy protein,Dystrophin,Muscular dystrophy Duchenne and Becker types
Host：Rabbit
Reactivity：Human,Mouse
Applications：IHC,ELISA
Concentration：0.2mg/mL
Immunogen：Recombinant protein of human DMD
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：25-1：100
Swissprot：P11532
Isotype：IgG
Research Areas：Cancer, Neuroscience, Signal transduction, Stem cells
