Background：The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
仕様
Synonyms：COM1,COM1,CtBP interacting protein,CtBP-interacting protein,CtIP,DNA endonuclease RBBP8,JWDS,RB binding protein 8 endonuclease,RBBP-8,RBBP8,Retinoblastoma-binding protein 8,Retinoblastoma-interacting protein and myosin-like,Rim,SAE2,SCKL2,Sporulation in the absence of SPO11 protein 2 homolog
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.6mg/mL
Immunogen：Recombinant protein of human RBBP8
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：100-1：300
Swissprot：Q99708
Isotype：IgG
Research Areas：Cancer, Epigenetics and Nuclear Signaling
