Background：Pleckstrin homology domain-containing family O member 1is aproteinthat in humans is encoded by thePLEKHO1gene. Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein （CP）. May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 （CK2）. Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity （plasma membrane bound AP-1 regulator that translocates to the nucleus） and the promotion of apoptosis induced by tumor necrosis factor TNF.
仕様
Synonyms：C-Jun-binding protein,Casein kinase 2-interacting protein 1,CK2 interacting protein 1,CK2 interacting protein 1 HQ0024c protein,CK2-interacting protein 1,CKIP 1,CKIP-1,CKIP1,JBP,OC120,Osteoclast maturation associated gene 120 protein,Osteoclast maturation-associated gene 120 protein,PH domain-containing family O member 1,PKHO1,Pleckstrin homology domain containing family O member 1,Pleckstrin homology domain-containing family O member 1,PLEKHO1
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.4mg/mL
Immunogen：Recombinant protein of human PLEKHO1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
