Background：VWA5A （von Willebrand factor A domain containing 5A）, also known as BCSC-1 （breast cancer suppressor candidate 1） or LOH11CR2A （loss of heterozygosity 11 chromosomal region 2 gene A protein）, is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80％ of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity （LOH） in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A.
仕様
Synonyms：BCSC1,BCSC-1,LOH11CR2A
Host：Rabbit
Reactivity：Human
Applications：WB,IHC,ELISA
Concentration：0.5mg/mL
Immunogen：Recombinant protein of human VWA5A
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
