Background：Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta （TGF-beta） superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I （ I and IB） and two type II （II and IIB） receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors.
仕様
Synonyms：Activin A receptor type I,Activin A receptor type II like kinase 2,Activin receptor type I,Activin receptor type-1,Activin receptor-like kinase 2,ACTR-I,ACTRI,Acvr1,ACVR1,ACVR1A,ACVRLK2,ALK 2,ALK-2,ALK2,FOP,Hydroxyalkyl protein kinase,Serine/threonine-protein kinase receptor R1,SKR1,TGF-B superfamily receptor type I,TGFB superfamily receptor type I,TSR-I,TSRI
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.6mg/mL
Immunogen：Recombinant protein of human ACVR1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：Q04771
Isotype：IgG
Research Areas：Epigenetics and Nuclear Signaling, Signal transduction, Stem cells
