Background：BMI1polycombring fingeroncogene, also known asBMI1, is aproteinwhich in humans is encoded by theBMI1gene. Component of a Polycomb group （PcG） multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
仕様
Synonyms：B lymphoma Mo MLV insertion region （mouse）,B lymphoma Mo MLV insertion region 1 homolog,Bmi 1,BMI1,BMI1 polycomb ring finger oncogene,BMI1,Flvi 2/bmi 1,FLVI2/BMI1,MGC12685,Murine leukemia viral （bmi 1） oncogene homolog,Oncogene BMI 1,PCGF 4,PCGF4,Polycomb complex protein BMI 1,Polycomb complex protein BMI-1,Polycomb group protein Bmi1,Polycomb group ring finger 4,Polycomb group RING finger protein 4,RING finger protein 51,RNF 51,RNF51
Host：Rabbit
Reactivity：Human,Mouse
Applications：WB,ELISA
Concentration：0.3mg/mL
Immunogen：Recombinant protein of human BMI1
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：WB 1：200-1：1000
Swissprot：P35226
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Stem cells
