Background：STK40 （Serine/threonine-protein kinase 40）, also known as Sugen kinase 495, is a 435 amino acid protein kinase that may be a negative regulator of NFkappaB and p53-mediated gene expression. Localized to both the cytoplasm and the nucleus, STK40 is ubiquitously expressed. STK40 has a central serine/threonine protein kinase domain and is homologous to TRB-3, a protein that regulates activation of MAP kinases and inhibits NFkappaB-mediated gene transcription. Similarly, overexpression of STK40 inhibits NFkappaB activation triggered by TNF and also inhibits p53-mediated transcription. There are four named isoforms of STK40 that are produced as a result of alternative splicing.
仕様
Synonyms：2310004N11Rik,MGC4796,OTTHUMP00000009948,OTTHUMP00000009951,RP11-268J15.4,Ser/Thr like kinase,Serine/threonine kinase 40,Serine/threonine protein kinase 40,SgK495,SHIK,SINK homologous serine/threonine protein kinase,SINK-homologous inhibitory kinase,STK 40,Sugen kinase 495
Host：Rabbit
Reactivity：Human,Mouse,Rat
Applications：IHC,ELISA
Concentration：0.3mg/mL
Immunogen：Recombinant protein of human STK40
Purification Method：Affinity purification
Clonality：Polyclonal
Conjugation：Unconjugated
Buffer：PBS with 0.05％ sodium azide, 50％ glycerol, PH7.3
Dilution：IHC 1：50-1：200
Swissprot：Q8N2I9
Isotype：IgG
Research Areas：Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal transduction
