Background：The protein encoded by this gene is a Rho-like GTPase that switches between the active （GTP-bound） state and inactive （GDP-bound） state to regulate CDC42 and other genes. Defects in this gene are a cause of startle disease with epilepsy （STHEE）, also known as hyperekplexia with epilepsy. Three transcript variants encoding different isoforms have been found for this gene.
